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Soonchunhyang Medical Science 2010;16(2): 265-268.
자연기흉에서 미노사이클린 흉막유착술의 효과: 타크와의 비교
이석열, 백강석, 이승진, 이철세
The Effects of Minocycline Pleurodesis in Spontaneous Pneumothorax: Comparison with Talc
Seock Yeol Lee, Kang Seok Baek, Seung Jin Lee, Cheol Sae Lee
Corresponding Author: Seock Yeol Lee ,Tel: +82-41-570-2190, Fax: +82-41-575-9674, Email: csdoctor@schmc.ac.kr
Primal drugs are tetracycline and talc in chemical pleurodesis. But they are not available. Therefore, we performed chemical pleurodesis using minocycline in patients with spontaneous pneumothorax and compared with talc pleurodesis. And we observed the effects and efficiency of treatment. From March 2004 to February 2010, spontaneous pneumothorax patients whose continuous air leakage lasted more than 5 days but for whom surgery were not indicated or didn’t want surgery underwent chemical pleurodesis with minocycline and talc. Sixteen pneumothorax patients were studied in minocycline pleurodesis group. And 22 pneumothorax patients were studied in talc pleurodesis group. Continuous air leakages disappeared in 13 patients (81.3%) among the 16 minocycline pleurodesis group and in 20 patients (90.9%) among the 22 talc pleurodesis group. Complications included chest pain in all 14 patients (87.5%), leukocytosis in 10 patients (62.5%), fever and chill in 7 patients (43.6%) in minocycline pleurodesis group and chest pain in all 19 patients (86.4%), leukocytosis in 17 patients (77.3%), fever and chill in 14 patients (63.6%) in talc pleurodesis group. Our findings demonstrated that minocycline pleurodesis had less effect than talc pleurodesis but had good results with acceptable complications. However, long term follow-up is necessary to evaluate the accurate effects of treatment and recurrence in a large number of patients.
Key words: Pneumothorax; Pleurodesis; Air leakage; Minocycline; Talc
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